At 21st.BIO, we're not just another biotech company, we are the vanguards of a revolution. Fueled by the determination to shape a more sustainable world, we are developing a technology platform that will profoundly disrupt the global landscape. Our dream? To engineer the future of sustainable foods and materials through the art of fermentation.

Our Team

Our R&D facility in Davis, California, integrates expertise across strain engineering, protein and analytical chemistry, and lab-scale fermentation. We are a fast-growing, innovation-driven team that values trust, respect, and scientific curiosity. Collaboration across disciplines is central to our culture, fueling bold ideas and breakthrough results that advance the frontiers of biotechnology.

Position Overview

We are seeking a highly motivated Scientist in Analytical Chemistry to join our team. The successful candidate will be responsible for the development and execution of analytical methods to support protein characterization and quantification. This role is central to ensuring product quality and advancing our precision fermentation pipeline.

Responsibilities

Develop, optimize, and execute analytical methods for protein characterization, including HPLC/UPLC (SEC, RP, HIC, HILIC) and LC-MS

Support quantification of proteins and metabolites from fermentation samples.

Perform protein characterization by LC–MS, including intact mass analysis and peptide mapping, to confirm sequence and integrity of expressed proteins.

Analyze and quantify post-translational modifications (e.g., glycosylation, oxidation, phosphorylation, deamidation) and support disulfide bond studies.

Develop, optimize, and troubleshoot LC–MS methods for protein and peptide analysis, ensuring robustness and reproducibility.

Process and interpret both HPLC and LC–MS data, generate clear reports, and present findings to cross-functional teams.

Partner with fermentation and downstream processing teams to provide analytical insights that guide protein production strategies.

Maintain accurate laboratory records, analyze data, and prepare technical reports.

Assist in troubleshooting and maintaining analytical instrumentation.

Communicate results and findings to scientists within the project group

Ensure adherence to laboratory safety protocols and best practices.

Qualifications

Required:

B.S. with 8 years of experience, MS, or PhD in Chemistry, Biochemistry, Biotechnology, or related field.

Hands-on experience with protein analysis using techniques such as HPLC/UPLC and LC-QTOFMS

Proficiency in data analysis software for chromatography and mass spectrometry.

Strong problem-solving, organizational, and communication skills.

Ability to work independently and collaboratively in a fast-paced biotech environment.

Positive can-do attitude and self-motivation

Experience with Agilent MassHunter and Chemstation is a plus but is not required

Why 21st.BIO?

We may still be a small company, but we dream big. We're a vibrant consortium of thinkers, researchers, and visionaries bound by the shared dream of a greener tomorrow.

Based in Søborg (Denmark) and Davis (California), we work with our customers to accelerate the World’s quest for new sustainable food and materials. We build a competitive technology and manufacturing foundation to enable the commercialization of new, innovative products that are more sustainable than traditional offerings.

We support our customers from strain development to scale-up, with the objective of bringing their products successfully to market.

Joining our team means

Personal and professional growth in a hub of innovation and disruptive thinking.

A supportive workplace where your growth, well-being, and empowerment come first.

The opportunity to work alongside a team of industry experts.

A competitive salary and benefits package.

More info

You will join our site in Davis, California. If you want to hear more about the position and the company, please contact Abigail Jang at a.jang@21st.bio.

Annual salary: $90,000 – 110,000 USD.

The position is expected to be in-person at our vibrant R&D site in Davis, CA.

21st.BIO is an Equal Opportunity Employer and we value diversity at our company. We do not discriminate based on race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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