UMAMI Bioworks is the leading bioplatform for the development and production of sustainable blue biosolutions. Through the synthesis of machine learning, multi-omics biomarkers, and digital twins, UMAMI has established market-leading capability for discovery and development of cultivated blue bioproducts and services serving industries from human food to cosmetics to pet nutrition.
By partnering with market leaders as their biomanufacturing solution provider, UMAMI is democratizing access to sustainable blue bioeconomy solutions that address a wide range of global challenges.
We’re a venture-backed biotech company located in Singapore where some of the world’s smartest, most passionate people are pioneering a sustainable food future that is attractive and accessible to people around the world. We are united by our collective drive to ask tough questions, take on challenging problems, and apply cutting-edge science and engineering to create a better future for humanity. At Umami Bioworks, you will be encouraged to dream big and will have the freedom to create, invent, and do the best, most impactful work of your career.
Umami Bioworks is looking to hire an inquisitive, innovative, and independent Upstream Bioprocess Lead to join our R&D team in Bangalore, India.
Role Overview
Bioprocess Engineer to lead our Process Engineering team to guide development of our continuous cultivation process to production scale and successfully transfer production to customer-operated sites. In this role, you will be responsible for leading the process development of cultivated fish cell culture scale-up, from static and small-scale dynamic culture to 200+ L. This will require experimental design, wet-lab work, and data analysis for cell proliferation at increasing scale.
Successful candidates will be expected to drive upstream process development activities, develop and clearly communicate requirements to inputs teams, and will bring expertise in operating scale-down bioreactors, developing optimized bioprocesses, and scaling process from bench to pilot. You will work directly with other members of our small but growing team to do cutting-edge science and will have the autonomy to test new ideas and identify better ways to do things.
Key Responsibilities
Research and Development: Design and execute DoE-driven studies across shake flasks, bench, and pilot bioreactors to optimize media, feeding, and process parameters. Implement and refine process control, and feed profiles
Process Development & Optimization: Design and execute experiments to develop, characterize and optimize scalable upstream (e.g., cell culture) and downstream (e.g., purification) processes for new species in our pipeline.
Scale-Up Leadership: Apply scientific and engineering principles to scale processes from benchtop bioreactors to pilot-scale equipment, identifying and mitigating potential risks.
Supply Chain Optimization: Analyze process economics and critical suppliers to identify and implement strategies that reduce COGS while maintaining product quality.
Documentation & Reporting: Author and review key technical documents, including development reports, batch records, and Standard Operating Procedures (SOPs) for internal records and handover to customers under license.
Regulatory readiness: Support preparation of regulatory dossiers by generating and providing all process documentation and data packages in the format and level of detail required to support global regulatory requirements.
Collaboration: Work closely with cross-functional teams, including R&D, Manufacturing, Quality, and Engineering, to ensure project goals and timelines are met.
Mentorship: Provide technical guidance and mentorship to junior scientists and associates within the team.
Qualifications
PhD in Chemical Engineering, Biotechnology or related field + 5 years or M.S + 7 years of relevant industrial hands-on experience
Experience
8-10 years in MSAT and production with direct experience in scaling animal cell culture processes from R&D reactors (<50L) to production reactors of at least 200L
5+ years of industry experience (MS) or 3+ years of industry experience (PhD) in biotechnology, cell manufacturing or a relevant engineering field
Demonstrated expertise in process scale-up and with successful technology transfer of multiple animal cell products from pilot to commercial scale
Experience with batch and fed-batch cell culture is essential; intensified or continuous process experience is a plus
Experience with scale-down model development, predictive modeling, and model validation is a plus
Experience with high-throughput, parallel bioreactor systems and automation is a plus
Track record of successfully leading small teams is strongly preferred
Demonstrated scientific rigor toward continuous improvement
Skills
Strong understanding of upstream processes, process analytical technologies, and troubleshooting approaches for successful bioprocess transfers
Proficiency with Design of Experiments (DOE) methodology for bioprocess development, including experiment design and data analysis
Proficiency in engineering techniques, including quantitative modeling and mass balance
Basic scripting in relevant languages such as Python, R, SQL, etc
Ability to work in a fast-paced, dynamic environment and skills to prioritize and deliver against timelines
Strong troubleshooting and problem-solving skills
Excellent written and verbal communication skills, including strong command of the English language
You will work directly with other members of our small but growing team to do cutting-edge science and will have the autonomy to test new ideas and identify better ways to do things.
