Arzeda is solving some of today's hardest and most meaningful problems – from food and nutrition to sustainable materials and homecare – by designing proteins that have the limitless potential to change everyone's daily life. Our team has developed a proven technology platform that merges computational protein design, machine learning, and synthetic biology tools to produce proteins, enzymes, and bio-based processes more efficiently than Mother Nature.
We are seeking a detail-oriented Scientist to join our highly collaborative Protein Testing Team. You will play a critical role in the continued development of our enzyme engineering platform at Arzeda to rapidly screen and optimize enzyme functions by developing high-throughput, automation-ready assay workflows that accelerate enzyme screening, characterization, and experimental iteration.
Arzeda is located in Seattle, Washington, among the historic and artistic neighborhoods of Ballard, Fremont and Queen Anne.
Requirements:
• You must have electrochemistry background.
• You must have enzymology experience.
Responsibilities:
• Develop robust high throughput enzyme assays for bioelectro-conversions or bioconversions.
• Evaluate enzyme performance using electrochemical assays, and traditional enzyme assays, using absorbance, fluorescence, and HPLC/MS to detect and quantify products, cofactors, and reaction mediators.
• Contribute to and become an owner of experimental design to drive efficient identification of enzymes with desired properties.
• Perform cell-free expression, and high-throughput or mid-scale protein preparation, as needed.
• Design, optimize, and scale automation-compatible assay workflows to increase experimental throughput, reproducibility, and data quality.
• Partner with automation, software, and data infrastructure teams to implement robotic liquid handling, assay orchestration, and streamlined data analysis pipelines.
• Identify experimental bottlenecks and develop strategies to reduce assay cycle time and increase design-build-test-learn iteration speed.
• Develop, optimize, and perform laboratory SOPs.
• Interface with upstream and downstream teams for efficient data exchange and transfer of materials.
• Operate and maintain electrochemistry equipment.
Qualifications:
• Ph.D. in Bioelectrocatalysis, Biocatalysis, Biochemistry, Chemical Biology, Chemistry or other related field, or 4+ years of experience in a Masters or industry role.
• In-depth knowledge and hands-on experience with enzyme characterization.
• Experience developing enzyme assays, especially for biocatalysis or bioconversions.
• Experience designing or operating automated experimental workflows and high-throughput assay systems strongly preferred.
• Understanding of redox chemistry and thermodynamics.
• Experience developing and characterizing enzymes and enzyme-electrode interfaces including direct and/or mediated electron transfer using spectroscopic and electrochemical methods.
• Understanding of Marcus and Butler-Volmer theory pertaining to electrocatalysis.
• Experience working in a glovebox/bag.
• Experience evaluating data sets, putting together reports, and presenting findings and/or results from data analysis.
Nice-to-haves:
• Python and/or R
• Hands-on experience with automation equipment
• Understanding of HPLC or LC/MS for small molecules and proteins.
Benefits:
• Base salary of $101,000 to $140,000 depending on experience
• Comprehensive compensation package, to include equity
• Paid time off; company-observed holidays to include a company paid holiday closure between Dec 25 and Jan 1; and paid medical/family leave
• Excellent medical, dental, and vision insurance to include options for Health Savings Accounts
• 401(k) retirement savings plan
• Commuter benefits
Legal authorization to work in the United States is required. Arzeda will not sponsor a new H1-B visa.
Arzeda is an equal opportunity employer promoting diversity and inclusion in the workspace.
For more information or to apply, please visit the original posting.
