Scientist, Molecular Biology
Triplebar is on a mission to learn the language of biology using generative AI. We’re building cutting-edge large language models trained directly on millions of genomes, powered by the largest biological data engine on Earth. Our hyperthroughput platform evolves and screens biology at unprecedented scale, generating the data needed to teach machines how to design cells that can make anything.
We call this Evolutionary Intelligence: a new way to engineer biology, grounded in real data and aimed at solving the toughest problems in industrial biotech. Our first targets: protein production in microbial (Pichia pastoris) and mammalian (CHO) systems. Our goal: compress the timeline for designing an organism to produce any protein from years to seconds.
We’re looking for a driven, creative scientist to own the development and deployment of CRISPR-based genome engineering tools that power our core platform. You’ll take the predictions from our genome language models and make them real, starting with Pichia and expanding across systems. You’ll collaborate with a tight-knit, world-class team spanning machine learning, automation, and hyperthroughput screening.
This is not just a job. It’s a chance to build something truly new, at the edge of what’s possible. If you want to go fast, go deep, work hard, and make a dent in the universe, we want to meet you.
The role
As a full-time Scientist at Triplebar, you’ll lead the design and deployment of CRISPR-based tools for Pichia pastoris and other production organisms. You’ll be building the molecular biology infrastructure that powers our core technology—turning AI-driven predictions into engineered strains, fast.
You’ll take full ownership of key experiments, from design through execution and analysis. Your work will drive critical proof-of-concept studies, shape partner programs, and directly impact how we build and train the next generation of genome language models. Precision, creativity, and scientific rigor are all essential—you’ll be working at the heart of a platform that moves fast and scales large.
This is a hands-on, high-impact role at the cutting edge of synthetic biology, perfect for someone who’s ready to be part of building the future.
Your Contributions
Leverage your deep strain/cell line engineering expertise to design and deploy CRISPR systems, from the bench, for Pichia
Develop library strategies to create genetic edits suggested by Triplebar’s genome language models
Build strains and libraries to validate Triplebar’s genome language models, infuse data sets with validated data points
Perform high throughput assays to evaluate production of built strains
Work closely with genome language model team (machine learning focus) on scientific basis and learning from genome language models
Build company culture and serve as a role model for future hires
About you
Doctorate degree in microbiology, genetics, biochemistry, bioengineering or related field.
5+ years experience engineering Pichia in a fast-paced collaborative industrial environment.
Have deployed CRISPR in Pichia or other yeast or fungal system. Have executed hands on CRISPR-based builds for a variety of edit types in large quantities: SNPs, insertions, deletions.
Have managed large quantities of DNA design and orders. Have worked with a variety of synthetic DNA providers
Experience with next generation sequencing workflows
Experience culturing and assaying Pichia for protein production, including microtiter plate and other high throughput methods
Highly-motivated, self-starter with a track record of identifying issues, providing solutions and aligning with project teams to rapidly meet the team’s goals.
Based in Santa Monica-area, role will be on site
Not required, but exceptional candidates would also have...
Deployed CRISPR in CHO or other mammalian systems. Have executed hands on build for a variety of edit types in large quantities: SNPs, insertions, deletions.
Proficiency with Python, R, JMP, Spotfire or other data visualization and statistical tools
Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. This position is based in our Santa Monica, CA location.
