Position Summary
We are seeking an experienced Senior Scientist to lead efforts in antibody discovery and developability characterization. This individual will play a critical role in advancing our antibody discovery, production, and characterization platform by applying state-of-the-art biophysical and functional assays to assess antibody properties. The ideal candidate will bring expertise in antibody engineering, developability assessments, and lead selection strategies.
Key Responsibilities
- Lead method development and execution of antibody production and characterization workflows to support platform programs.
- Design, develop, and execute biophysical and functional assays to evaluate antibody binding, stability, and activity across a range of assays, for various antibody formats (IgGs, Vhh, minibinders, Fabs, bi- and multi-specifics, etc).
- Conduct in-depth developability assessments including binding kinetics, thermal/colloidal stability, polyreactivity, aggregation propensity, etc.
- Support the onboarding of any relevant assays to automated high-throughput platforms.
- Provide technical leadership in antibody engineering, affinity maturation, and optimization strategies.
- Mentor junior scientists and contribute to scientific strategy and innovation.
- Author technical reports, SOPs, and present findings to internal leadership and external customers
Required Qualifications
- Ph.D. in Biochemistry, Immunology, Bioengineering, or a related field with 2+ years of industry experience in antibody discovery and characterization (or M.S. with 6+ years of industry experience).
- Expertise in antibody engineering, production (transfection and purification), and developability characterization using biophysical and biological techniques.
- Extensive hands-on expertise with SPR and BLI for quantitative antibody-antigen interaction analysis
- Demonstrated proficiency in antibody developability assessment using multiple biophysical techniques (DSF, DLS, SEC, HIC, AC-SINS, Polyreactivity, etc.)
- Proven ability to lead projects and mentor junior scientists in an industry setting.
- Excellent communication skills and ability to work in a multidisciplinary environment.
Preferred Qualifications
- Industry experience in therapeutic antibody discovery and development.
- Experience in discovery, production and characterization of bi- and multi-specifics
- Familiarity with automation and high-throughput screening techniques.
- Knowledge of antibody display platform is desirable
