Scientist, CHO cell line engineering
Triplebar is on a mission to learn the language of biology using generative AI. We’re building cutting-edge models trained directly on millions of genomes, powered by the largest biological data engine on Earth. Our hyperthroughput platform evolves and screens biology at unprecedented scale, generating the data needed to teach machines how to design cells that can make anything.
We call this Evolutionary Intelligence: a new way to engineer biology, grounded in real data and aimed at solving the toughest problems in industrial biotech. Our first targets: protein production in microbial (Pichia pastoris) and mammalian (CHO) systems. Our goal: compress the timeline for designing an organism to produce any protein from years to seconds.
We’re looking for a driven, creative scientist to create the next generation mammalian expression platform for large molecule therapeutics. You’ll bring experience with CHO cell line development (CLD) and engineering to a team that is creating the largest dataset of genotype-phenotype relationships for biologics manufacturing with CHO and combine them to dramatically improve the efficiency of biomanufacturing.
This is not just a job. It’s a chance to build something truly new, at the edge of what’s possible. If you want to go fast, dive deep, work hard, and make a dent in the universe, we want to meet you.
The role
As a full-time Scientist at Triplebar, you’ll use genome scale directed evolution to uncover novel mechanisms for improving CHO secretion, and then engineer cells to take advantage of those mechanisms to achieve high performance. You’ll leverage deep experience and a state of the art understanding of how to do CLD, and extend it to optimizing cell lines for new heights of performance. Creativity and scientific rigor are all essential—you’ll have to challenge a lot of assumptions in current CLD workflows to achieve the level of performance required.
This is a hands-on, high-impact role at the cutting edge of biological engineering, perfect for someone who’s ready to be part of building the future.
Your Contributions
Design, improve, and operate our CHO cell line improvement platform, including microfluidic and automation enabled screening, fed batch testing, and targeted cellular engineering.
Bring a wealth of knowledge on CLD processes to ensure that we are building on the state of the art, not re-inventing the wheel.
Develop automation solutions to increase throughput and improve robustness of cell culture processes including cloning, passaging, and fed batch screening.
Engage with customers and partners in a compelling, professional, and transparent manner.
Systematically test theories/hypotheses and drive conclusive results.
Take initiative to identify new areas for improvement and seek out new responsibilities.
Own results by making data-driven decisions, presenting results, and documenting findings.
Work closely with other parts of the org (assay development, ML/bioinformatics) to ensure the work fits into the larger Triplebar platform
Build company culture and serve as a role model for future hires
About you
PhD with 5+ years of CHO cell line development and/or engineering
Demonstrated expertise in generating high performing clones expressing therapeutic large molecules
A deep understanding of the connection between cell line engineering, clone selection, and transfer to bioreactor scale.
Demonstrated experience in partner facing scientific roles
Experience with automation and robotics to increase the throughput of CHO cell culture and screening
Highly-motivated self-starter that identifies issues and is intellectually curious to expand into new fields.
Willingness to self-evaluate, learn, and expand.
Enthusiastic about wearing many hats in a young and growing organization.
Builds and earns trust with coworkers to achieve team goals.
Based in Santa Monica-area, role will be on site
Not required, but exceptional candidates would also have...
Experience using data analysis scripting language (e.g. Python, R, Matlab)
Experience with advanced instrumentation (e.g., flow cytometry, microscopy, chromatography)
Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. This position is based in our Los Angeles, CA location.
