Scientist, Assay development and screening
Triplebar is on a mission to learn the language of biology using generative AI. We’re building cutting-edge models trained directly on millions of genomes, powered by the largest biological data engine on Earth. Our hyperthroughput platform evolves and screens biology at unprecedented scale, generating the data needed to teach machines how to design cells that can make anything.
We call this Evolutionary Intelligence: a new way to engineer biology, grounded in real data and aimed at solving the toughest problems in industrial biotech. Our first targets: protein production in microbial (Pichia pastoris) and mammalian (CHO) systems. Our goal: compress the timeline for designing an organism to produce any protein from years to seconds.
We’re looking for a driven, creative scientist to build and improve creative assays for various phenotypes that are deployable in a microfluidics environment. You’ll design and build the molecular sensors that enable ultra-high throughput testing of relevant phenotypes at thousands per second. You’ll deploy the assays along with a diverse team of scientists and engineers to carry out synthetic organism evolution at massive scale.
This is not just a job. It’s a chance to build something truly new, at the edge of what’s possible. If you want to go fast, dive deep, work hard, and make a dent in the universe, we want to meet you.
The role
As a full-time Scientist at Triplebar, you’ll create numerous assays that test the phenotypes that matter. Triplebar is scaling up the number of programs we run and the types of products we are building, and the heart of that expansion is new robust assays. You’ll learn from what we have done already and expand on those ideas to create accurate and precise sensing systems, and then you’ll use those assays to screen millions of organisms. Creativity and scientific rigor are all essential—you’ll have to challenge a lot of assumptions to achieve the level of throughput, accuracy and precision required.
This is a hands-on, high-impact role at the cutting edge of synthetic biology, perfect for someone who’s ready to be part of building the future.
Your Contributions
Develop and deploy light based assays for complex cellular phenotypes like protein secretion or immune synapse formation
Bring a wealth of knowledge on various assay modalities that can be deployed in a microfluidic context
Systematically test theories/hypotheses and drive conclusive results.
Own results by making data-driven decisions, presenting results, and documenting findings.
Work closely with other parts of the org ( microfluidics, cell line build, ML/bioinformatics) to ensure the work fits into the larger Triplebar platform
Build company culture and serve as a role model for future hires
About you
PhD with 2+ years of biotech/pharma industry experience, or equivalent experience with a Masters/Bachelors Degree.
Demonstrated expertise in developing multiple assays that resulted in successful identification of improved enzymes or strains.
Demonstrated experience in defining assay requirements and achieving them through clear experimentation and analysis
A deep understanding of assay modalities that can be deployed against various phenotypes
Highly-motivated self-starter that identifies issues and is intellectually curious to expand into new fields.
Willingness to self-evaluate, learn, and expand.
Enthusiastic about wearing many hats in a young and growing organization.
Builds and earns trust with coworkers to achieve team goals.
Based in Santa Monica-area, role will be on site
Not required, but exceptional candidates would also have...
Experience with protein production and purification methods: Cell-free, E. coli, IEC, SEC etc.
Experience with biosensor discovery methods: Phage or Yeast display, SELEX etc.
Experience using data analysis scripting language (e.g. Python, R, Matlab)
High-throughput automation, robotics engineering experience
Legal authorization to work in the U.S. is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. This position is based in our Los Angeles, CA location.
